International Circulation: Could you discuss with us about the mechanism of direct renin and inhibition of anti-hypertension in cardio-renal protection?

国际循环:能否请您谈论一下直接肾素和抗高血压抑制在心肾保护中的机制？

Gonzalez Juanatey:  The plasma renin activity was closely related to vascular and kidney diseases.  This has seemed to be the case for years but recently a number of studies in post myocardial infarction (MI) patients and patients with chronic ischemic heart disease as well as hypertensive patients suggests that plasma renin activity is a marker and probably also is an important mechanism for removing vascular damage and kidney damage.  The problem is， at the present time， that we don’t have a drug to reduce or interfere with the plasma renin activity.  Plasma renin activity is a powerful risk factor for vascular and kidney dysfunction.

Gonzalez Juanatey教授: 血浆肾素活性与血管和肾脏疾病密切相关。虽然这一事实似乎是已知多年的，但是最近诸多在心肌梗死（MI）后患者和慢性缺血性心脏病以及高血压患者中进行的研究提示，血浆肾素活性是一种标记物，而且很可能也是消除血管损伤和肾脏损伤的重要机制之一。目前的问题是我们并没有降低或者干扰血浆肾素活性的药物。血浆肾素活性是血管和肾脏功能不全的一个强烈危险因素。

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