当前位置:循环首页>正文

Incremental cost-effectiveness of drug-eluting stents compared with a third-generation bare-metal stent in a realworld setting: randomised Basel Stent Kosten Effektivitäts Trial (BASKET) 与第三代裸金属支架相比,临床实践中药物涂层支架增加患者的成本效益:BASKET研究

作者:国际循环网   日期:2005/9/9 0:00:00

国际循环网版权所有,谢绝任何形式转载,侵犯版权者必予法律追究。

Summary Background No prospective trial-based data are available for incremental cost-effectiveness of drug-eluting stents (DES) compared with bare-metal stents (BMS) in unselected patients, as treated in everyday practice. Methods The Basel stent cost-effectiveness trial (BASKET) included 826 consecutive patients treated with angioplasty and stenting for 1281 de-novo lesions, irrespective of indication for angioplasty. Patients were randomised to one of two DES (Cypher, n=264; Taxus, n=281) or to a cobalt-chromium-based BMS (Vision, n=281) and followed up for 6 months for occurrence of major adverse cardiac events and costs. Analysis was by intention-totreat. The primary endpoint was cost-effectiveness after 6 months, with effectiveness defined as reduction of major adverse cardiac events. Findings Cardiac death, myocardial infarction, or target vessel revascularisation occurred in 39 of 544 (7·2%) patients with DES and 34 of 280 (12·1%) with BMS (odds ratio 0·56, 95% CI 0·35–0·91; p=0·02), without significant differences between the two DES. Total costs at 6 months were higher with DES (mean €10544, SD 6849) than with BMS (€9639, 9067; p 0·0001); higher stent costs of DES were not compensated for by lower follow-up costs. Incremental cost-effectiveness ratio of DES compared with BMS to avoid one major event was €18311, and costs per quality-adjusted life-year gained were more than €50 000. Subgroup analyses showed that DES were more costeffective for elderly patients in specific high-risk groups. Interpretation In a real-world setting, use of DES in all patients is less cost effective than in studies with selected patients. Use of these stents could be restricted to patients in high-risk groups. 相关幻灯:BASKET PDF全文:PDF

版面编辑:国际循环



BASKET

分享到: 更多


设为首页 | 加入收藏 | 关于我们 | 联系方式 | 招贤纳士
声明:国际循环网( www.icirculation.com)对刊载的所有文章、视频、幻灯、音频等资源拥有全部版权。未经本站许可,不得转载。
京ICP备15014970号-5  互联网药品信息服务资格证书编号(京)-非经营性-2017-0063  京公网安备 11010502033353号  增值电信业务经营许可证:京ICP证150541号
国际循环 版权所有   © 2004-2024 www.icirculation.com All Rights Reserved
公司名称:北京美赞广告有限公司 公司地址:北京市朝阳区朝阳门北大街乙12号天辰大厦1座1409 电话:010-51295530